Mesenchymal stromal/stem cell (MSC) therapies are currently being explored for dental pulp regeneration.As the therapeutic effects of MSCs in tissue repair are mediated mainly through the release of extracellular vesicles (EVs) including exosomes, we investigated here the cellular processes and molecular mechanisms modulated by MSC exosomes in dent
Abstract Angiogenesis is a multi-factorial physiological process deregulated in human diseases characterised by excessive or insufficient blood vessel formation.Emerging evidence highlights a novel role for microRNAs as regulators of angiogenesis.Previous studies addressing the effect of miR-133a expression in endothelial cells during blood vessel
Abstract Background Somatic copy number alternation (SCNA) is a common feature of the cancer genome and is associated with cancer etiology and prognosis.The allele-specific SCNA analysis of a tumor sample aims to identify the allele-specific copy numbers of both alleles, adjusting for the ploidy and the tumor purity.Next generation sequencing platf
Low-grade glioma is characterized by slow growth, infiltrative pattern through white matter tracts and progression to a malignant tumour type.The traditional classification is newly replaced by molecular stratification.This reorganisation gathers glioma with similar prognosis and treatment protocols.The preferential location of that tumour in eloqu
Abstract Background The homing of human mesenchymal stem cells (hMSCs) is crucial for their therapeutic efficacy and is characterized by the orchestrated regulation of multiple signaling modules.However, the principal upstream regulators that synchronize these signaling pathways and their mechanisms during cellular migration remain largely unexplor